Article published the 30 May. 2016
Sens-is awareness test
The Sens-is sensitization test, initially developed by Immunosearch, is based on the use of a reconstructed skin model (Episkin®) and the evaluation by RT-PCR of the expression of 62 genes selected as being relevant in the biological sensitization process.
While most tests currently available for the assessment of sensitization only give a qualitative response, Sens-is is the only test giving a quantitative response that correlates with the mouse model of LLNA (OECD TG 429) .
Advantages of the Sens-is test
- Quantitative assessment in correlation with the LLNA
- Episkin ® reconstituted epidermis
- Currently being validated by the OECD
Sens-is compared to other tests
Publications and posters:
- Cottrez F, SENS-IS , a 3D reconstituted epidermis based model for quantifying chemical sensitization potency: Reproducibility and predictivity results from an inter-laboratory study , Toxicol in vitro, June 2015.
- Cottrez F, Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay , Toxicol in vitro, April 2016.
